Across TCGA cell cohorts, SERPINA11 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINA11-associated genes across cancer lineages are OR2AK2, OR13C5, and GTSF1L. Each is linked with SERPINA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA11-to-partner and partner-to-SERPINA11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA11→partner) and Y-score (partner→SERPINA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2AK2 →	+0.027	+5.362	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR13C5 →	+0.024	+3.947	<.001	.004	3	2
LUNG_NSCLC_LUAD	GTSF1L →	+0.028	+3.544	.004	.009	3	1
LUNG_NSCLC_LUAD	FAM71B →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR2T4 →	+0.024	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR2M3 →	+0.079	+4.189	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

SERPINA11 survival (RNA) · tumor vs normal (RNA) · all SERPINA11 data types