Across TCGA patient cohorts, SERINC4 mutation is significantly associated with the RNA expression of many other genes, with 2,142 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC4-associated genes across cancer lineages are H3C15, RN7SL316P, and HMX2. Each is linked with SERINC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC4-to-partner and partner-to-SERINC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC4→partner) and Y-score (partner→SERINC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	H3C15 →	+0.030	+4.020	<.001	.002	3	2
COAD	RN7SL316P →	+0.300	+3.214	.006	.005	3	2
UCEC	HMX2 →	+0.938	+4.258	<.001	<.001	3	2
UCEC	RNU6-618P →	+0.227	+2.162	.007	.004	3	2
UCEC	RN7SKP123 →	+0.170	+2.579	<.001	.001	3	2
UCEC	IGKV2-19 →	+0.108	+2.694	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,142 associations by consensus.

Exploration

SERINC4 survival (RNA) · tumor vs normal (RNA) · all SERINC4 data types