SERINC2

Across TCGA patient cohorts, SERINC2 mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERINC2-associated genes across cancer lineages are MIR5583-1, MIR3908, and RNU6-218P. Each is linked with SERINC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC2-to-partner and partner-to-SERINC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5583-1 grouped by SERINC2-low versus SERINC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC2→partner) and Y-score (partner→SERINC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR5583-1 →	+0.515	+5.917	<.001	.001	3	2
COAD	MIR3908 →	+0.397	+6.734	<.001	<.001	3	2
UCEC	RNU6-218P →	+0.450	+2.126	.003	.004	3	2
BRCA	SNORA40C →	+0.538	+5.045	<.001	.009	3	2
BRCA	TSPY22P →	+0.053	+7.471	<.001	.008	3	2
LUAD	YBX1P9 →	+0.105	+5.343	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

MIR5583-1 by SERINC2 expression — COAD

Explore this box plot interactively →