SERINC2

Across TCGA cell cohorts, SERINC2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERINC2-associated genes across cancer lineages are MPC1L, OR10W1, and BTNL3. Each is linked with SERINC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERINC2-to-partner and partner-to-SERINC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPC1L grouped by SERINC2-low versus SERINC2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERINC2→partner) and Y-score (partner→SERINC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MPC1L →	+0.071	+4.000	<.001	.008	3	2
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	2
BONE	BTNL3 →	+0.005	+4.169	<.001	.008	3	1
BONE	OR1L6 →	+0.015	+4.169	<.001	.008	3	1
BONE	C2orf80 →	+0.095	+4.169	<.001	.008	3	1
BONE	POTEB →	+0.010	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MPC1L by SERINC2 expression — BONE

Explore this box plot interactively →