SERF2

Across TCGA patient cohorts, SERF2 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERF2-associated genes across cancer lineages are MIR548AZ, IGLVI-38, and ZYXP1. Each is linked with SERF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERF2-to-partner and partner-to-SERF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AZ grouped by SERF2-low versus SERF2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERF2→partner) and Y-score (partner→SERF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR548AZ →	+0.313	+7.954	<.001	.008	3	2
UCEC	IGLVI-38 →	+0.222	+4.146	<.001	.003	3	2
BRCA	ZYXP1 →	+0.248	+8.471	<.001	.005	3	1
BRCA	MIR3648-1 →	+0.534	+9.057	<.001	.003	3	1
UCEC	RNU6-90P →	+0.680	+3.927	.008	.007	3	1
UCEC	MIR6842 →	+0.640	+5.137	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

MIR548AZ by SERF2 expression — HNSC

Explore this box plot interactively →