SERAC1

Across TCGA patient cohorts, SERAC1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERAC1-associated genes across cancer lineages are mTOR_pS2448, Rad50, and EGFR_pY1068. Each is linked with SERAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERAC1-to-partner and partner-to-SERAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SERAC1-low versus SERAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERAC1→partner) and Y-score (partner→SERAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.152	-2.202	.005	.010	3	2
UCEC	Rad50 →	-0.214	-1.847	.016	.008	3	2
UCEC	EGFR_pY1068 →	-0.252	-3.700	.006	.001	3	1
UCEC	A-Raf_pS299 →	-0.104	-2.700	.018	.006	3	1
UCEC	Gab2 →	+0.270	+1.847	.039	.008	3	1
UCEC	IGFBP2 →	-0.680	-1.847	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

mTOR_pS2448 by SERAC1 expression — UCEC

Explore this box plot interactively →