SERAC1

Across TCGA cell cohorts, SERAC1 mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERAC1-associated genes across cancer lineages are AT7867, CD532, and GSK2110183B. Each is linked with SERAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERAC1-to-partner and partner-to-SERAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AT7867 grouped by SERAC1-low versus SERAC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERAC1→partner) and Y-score (partner→SERAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AT7867 →	+0.517	+2.652	.031	.045	3	1
LARGE_INTESTINE	CD532 →	+0.419	+2.652	.038	.045	3	1
LARGE_INTESTINE	GSK2110183B →	+0.608	+2.649	.046	.046	2	1
LARGE_INTESTINE	GSK690693 →	+0.770	+2.652	.001	.045	2	1
LARGE_INTESTINE	CP466722 →	+0.468	+2.652	.017	.045	1	1
LARGE_INTESTINE	IRAK4_4710 →	+0.548	+2.649	.001	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

AT7867 by SERAC1 expression — LARGE_INTESTINE

Explore this box plot interactively →