SEPTIN9-DT

Across TCGA pan-cancer cohorts, SEPTIN9-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SEPTIN9-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SEPTIN9-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN9-DT expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

KIRC, PAAD, and MESO are the cancer types where SEPTIN9-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.433	0.616	<.001	73	view →
PAAD	DFS	Tertile	All	0.176	0.483	<.001	50	view →
MESO	OS	Quartile	All	0.272	0.539	.002	42	view →
BLCA	DFS	Median	All	0.669	0.563	.006	34	view →
LUAD	OS	Median	III,IV	0.791	0.535	.004	21	view →
LUSC	DFS	Median	All	0.711	0.800	.001	16	view →
THCA	OS	Median	II,III,IV	1.000	0.930	.007	14	view →
THYM	DFS	Tertile	III,IV	1.000	0.209	.003	13	view →
SKCM	DFS	Quartile	All	0.803	0.708	.007	13	view →
UCS	OS	Tertile	III,IV	0.246	0.556	.024	12	view →
CESC	OS	Median	All	0.854	0.731	.004	12	view →
BRCA	DFS	Quartile	III,IV	0.923	0.805	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SEPTIN9-DT–KIRC (DFS)

Open the KIRC breakdown →