SEPTIN9-DT

Across TCGA pan-cancer cohorts, SEPTIN9-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEPTIN9-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SEPTIN9-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEPTIN9-DT is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where SEPTIN9-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN9-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+0.462	<.001	11	view →
COAD	Male	II,III,IV	−0.432	<.001	10	view →
KIRC	All	All	+0.135	.001	8	view →
LUSC	Female	II,III,IV	−1.074	<.001	7	view →
LUAD	Male	All	−0.601	<.001	7	view →
HNSC	Male	All	+0.520	.002	6	view →
UCEC	All	All	+0.363	<.001	6	view →
BRCA	Female	II,III,IV	+0.201	<.001	6	view →
KICH	Male	III,IV	−0.232	.003	5	view →
STAD	All	All	+0.295	.021	3	view →
PAAD	All	All	+0.940	.022	2	view →
PRAD	All	All	−0.189	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEPTIN9-DT–THCA

Open the THCA breakdown →