SEPTIN8

Across TCGA pan-cancer cohorts, SEPTIN8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEPTIN8 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SEPTIN8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEPTIN8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where SEPTIN8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.692	0.915	<.001	82	view →
GBM	OS	Tertile	All	0.160	0.537	.011	6	view →
CCRCC	DFS	Median	II,III,IV	0.199	0.839	.011	6	view →
LUAD	OS	Tertile	II,III,IV	0.871	0.324	.014	3	view →
PDAC	OS	Quartile	III,IV	0.977	0.458	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SEPTIN8–LSCC (OS)

Open the LSCC breakdown →