SEPTIN8

Across TCGA pan-cancer cohorts, SEPTIN8 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SEPTIN8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SEPTIN8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEPTIN8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LIHC, and STAD are the cancer types where SEPTIN8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.611	<.001	10	view →
LIHC	Female	II,III,IV	+1.545	<.001	9	view →
STAD	All	II,III,IV	+0.801	<.001	8	view →
KICH	Female	All	−1.119	<.001	7	view →
BLCA	All	III,IV	+0.835	.002	7	view →
BRCA	All	III,IV	+0.853	<.001	6	view →
LUAD	All	II,III,IV	+0.379	.007	4	view →
LUSC	All	All	+0.324	.002	4	view →
CHOL	All	All	+2.849	<.001	3	view →
KIRC	All	All	+0.366	<.001	3	view →
KIRP	All	IV	+0.877	.031	2	view →
UCEC	All	III,IV	+0.509	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SEPTIN8–COAD

Open the COAD breakdown →