SEPTIN8

Across TCGA patient cohorts, SEPTIN8 protein abundance is significantly associated with the RNA expression of many other genes, with 14,930 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SEPTIN8-associated genes across cancer lineages are LMOD1, IRAG1, and ZCCHC24. Each is linked with SEPTIN8 in more than 9 cancer types. Because this analysis shows association rather than direction, both SEPTIN8-to-partner and partner-to-SEPTIN8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPTIN8 versus LMOD1 in UCEC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN8→partner) and Y-score (partner→SEPTIN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1 →	+1.524	+0.277	<.001	<.001	3	10
GBM	IRAG1 →	+1.175	+0.507	<.001	<.001	3	10
COAD	ZCCHC24 →	+1.176	+0.290	<.001	<.001	3	9
BRCA	PODN →	+1.343	+0.381	<.001	<.001	3	9
UCEC	SFRP4 →	+1.897	+0.274	<.001	<.001	3	8
OV	PDGFRB →	+1.360	+0.391	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,930 associations by consensus.

SEPTIN8 vs LMOD1 — UCEC

Explore this scatter interactively →