SEPTIN8

Across TCGA patient cohorts, SEPTIN8 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN8-associated genes across cancer lineages are PCNA, 14-3-3_beta, and A-Raf_pS299. Each is linked with SEPTIN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN8-to-partner and partner-to-SEPTIN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SEPTIN8-low versus SEPTIN8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN8→partner) and Y-score (partner→SEPTIN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.285	+2.321	.001	.006	3	2
UCEC	14-3-3_beta →	-0.082	-2.973	.049	.035	3	1
UCEC	A-Raf_pS299 →	-0.138	-1.807	.005	.027	3	1
UCEC	ERK2 →	+0.192	+2.999	.015	.035	3	1
UCEC	JNK2 →	+0.226	+1.807	.005	.027	3	1
UCEC	Ku80 →	+0.244	+2.335	.012	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by SEPTIN8 expression — UCEC

Explore this box plot interactively →