SEPTIN8

Across TCGA cell cohorts, SEPTIN8 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SEPTIN8-associated genes across cancer lineages are MAGEB4, ZNF831, and CPO. Each is linked with SEPTIN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN8-to-partner and partner-to-SEPTIN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by SEPTIN8-low versus SEPTIN8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN8→partner) and Y-score (partner→SEPTIN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	ZNF831 →	+0.011	+3.103	<.001	.004	3	1
LARGE_INTESTINE	CPO →	+0.104	+3.514	.006	.007	3	1
LARGE_INTESTINE	GABRG1 →	+0.009	+3.518	<.001	.001	3	1
LARGE_INTESTINE	FAM153B →	+0.583	+3.618	<.001	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+3.518	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MAGEB4 by SEPTIN8 expression — LARGE_INTESTINE

Explore this box plot interactively →