SEPTIN8

Across TCGA cell cohorts, SEPTIN8 mutation is significantly associated with the mutation status of many other genes, with 3,197 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEPTIN8-associated genes across cancer lineages are PIGQ, LGI3, and FBXO46. Each is linked with SEPTIN8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPTIN8-to-partner and partner-to-SEPTIN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGQ grouped by SEPTIN8-low versus SEPTIN8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN8→partner) and Y-score (partner→SEPTIN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PIGQ →	+5.415	+5.415	.004	.004	1	3
BLOOD_Lymphoma	LGI3 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	FBXO46 →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	XYLT1 →	+4.429	+5.247	.005	.005	1	3
SKIN	GTF3C2 →	+5.392	+4.824	.004	.004	1	3
BLOOD_Lymphoma	RBM46 →	+4.014	+4.969	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,197 associations by consensus.

PIGQ by SEPTIN8 expression — OVARY

Explore this box plot interactively →