SEPTIN7

Across TCGA pan-cancer cohorts, SEPTIN7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEPTIN7 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEPTIN7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEPTIN7 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where SEPTIN7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	1.000	0.266	.002	18	view →
UCEC	OS	Tertile	III,IV	0.346	1.000	.024	12	view →
LSCC	OS	Quartile	All	0.607	1.000	.013	12	view →
HNSC	DFS	Tertile	All	0.520	0.737	.017	9	view →
PDAC	OS	Quartile	All	0.654	0.390	.043	4	view →
CCRCC	OS	Quartile	III,IV	0.912	0.517	.015	2	view →
GBM	OS	Median	All	0.938	0.783	.018	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEPTIN7–LUAD (DFS)

Open the LUAD breakdown →