SEPTIN4

Across TCGA pan-cancer cohorts, SEPTIN4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEPTIN4 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SEPTIN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

COAD, PDAC, and LUAD are the cancer types where SEPTIN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.778	1.000	.020	72	view →
PDAC	DFS	Median	All	0.853	0.671	<.001	46	view →
LUAD	DFS	Quartile	All	0.889	0.445	<.001	15	view →
LSCC	OS	Median	All	0.917	1.000	.006	12	view →
CCRCC	DFS	Quartile	III,IV	0.892	0.448	.008	7	view →
GBM	OS	Quartile	All	0.217	0.561	.015	2	view →
HNSC	OS	Tertile	II,III,IV	0.941	1.000	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEPTIN4–COAD (DFS)

Open the COAD breakdown →