SEPTIN4

Across TCGA pan-cancer cohorts, SEPTIN4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SEPTIN4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SEPTIN4 RNA is repressed in tumor relative to normal tissue. In most cancer types SEPTIN4 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KIRC, and KICH are the cancer types where SEPTIN4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.495	<.001	11	view →
KIRC	Female	All	+1.080	<.001	11	view →
KICH	Male	II,III,IV	−1.233	<.001	10	view →
KIRP	All	II,III,IV	−1.313	<.001	9	view →
LUSC	Female	II,III,IV	−1.894	<.001	8	view →
BRCA	All	All	−0.888	<.001	6	view →
CHOL	All	All	−1.231	<.001	2	view →
BLCA	Male	IV	−1.080	.006	2	view →
UCEC	All	All	−0.544	.029	2	view →
PRAD	All	All	−0.272	.001	2	view →
LIHC	Female	All	−0.675	.008	1	view →
THCA	All	IV	−0.675	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SEPTIN4–LUAD

Open the LUAD breakdown →