SEPTIN4

Across TCGA patient cohorts, SEPTIN4 mutation is significantly associated with the RNA expression of many other genes, with 3,160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN4-associated genes across cancer lineages are MIR2276, RNU6-874P, and RN7SKP93. Each is linked with SEPTIN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPTIN4-to-partner and partner-to-SEPTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR2276 grouped by SEPTIN4-low versus SEPTIN4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN4→partner) and Y-score (partner→SEPTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR2276 →	+0.184	+3.265	<.001	.006	3	3
COAD	RNU6-874P →	+0.774	+3.797	<.001	.003	3	2
COAD	RN7SKP93 →	+0.156	+4.595	.003	.004	3	2
COAD	RNU4-51P →	+0.556	+3.511	.002	.002	3	2
COAD	RNU6-425P →	+0.573	+4.399	<.001	.006	3	2
COAD	RNU6-1062P →	+0.761	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,160 associations by consensus.

MIR2276 by SEPTIN4 expression — SKCM

Explore this box plot interactively →