SEPTIN4

Across TCGA patient cohorts, SEPTIN4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN4-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and Caspase-8. Each is linked with SEPTIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN4-to-partner and partner-to-SEPTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by SEPTIN4-low versus SEPTIN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN4→partner) and Y-score (partner→SEPTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.226	-2.308	.004	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.883	+2.107	<.001	.002	3	2
UCEC	Caspase-8 →	-0.226	-3.060	.006	<.001	3	2
UCEC	4E-BP1 →	+0.240	+1.614	.007	.041	3	2
UCEC	C-Raf →	+0.170	+2.000	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.099	-2.195	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Rad50 by SEPTIN4 expression — UCEC

Explore this box plot interactively →