SEPTIN4

Across TCGA cell cohorts, SEPTIN4 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEPTIN4-associated genes across cancer lineages are SU11274, TWS119, and Torin 2. Each is linked with SEPTIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN4-to-partner and partner-to-SEPTIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SU11274 grouped by SEPTIN4-low versus SEPTIN4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN4→partner) and Y-score (partner→SEPTIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SU11274 →	+0.512	+2.652	.013	.045	3	1
LARGE_INTESTINE	TWS119 →	+0.542	+2.652	.020	.045	3	1
LARGE_INTESTINE	Torin 2 →	+0.737	+2.655	.005	.044	3	1
LARGE_INTESTINE	Dacarbazine →	+0.282	+2.777	.044	.038	2	1
LARGE_INTESTINE	Fulvestrant →	+0.384	+2.649	.024	.046	2	1
LARGE_INTESTINE	Voxtalisib →	+0.420	+2.652	.002	.045	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SU11274 by SEPTIN4 expression — LARGE_INTESTINE

Explore this box plot interactively →