SEPTIN4-AS1

Across TCGA pan-cancer cohorts, SEPTIN4-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SEPTIN4-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SEPTIN4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SEPTIN4-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

KIRC, LUAD, and SKCM are the cancer types where SEPTIN4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	II,III,IV	0.344	0.614	<.001	76	view →
LUAD	OS	Quartile	II,III,IV	0.668	0.432	.001	55	view →
SKCM	DFS	Quartile	III,IV	0.662	0.348	<.001	40	view →
DLBC	DFS	Median	All	0.622	0.890	.016	32	view →
LUSC	OS	Tertile	II,III,IV	0.504	0.738	.003	19	view →
ESCA	OS	Quartile	All	0.623	0.373	.016	14	view →
BRCA	DFS	Median	All	0.966	0.931	.007	12	view →
THCA	OS	Tertile	All	0.957	1.000	.015	12	view →
PCPG	DFS	Tertile	All	0.586	1.000	.003	10	view →
KICH	OS	Tertile	All	0.722	0.958	.025	7	view →
ACC	DFS	Median	II,III,IV	0.269	0.619	.023	7	view →
BLCA	DFS	Quartile	All	0.273	0.550	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SEPTIN4-AS1–KIRC (OS)

Open the KIRC breakdown →