SEPTIN4-AS1

Across TCGA pan-cancer cohorts, SEPTIN4-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SEPTIN4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SEPTIN4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SEPTIN4-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRP are the cancer types where SEPTIN4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.577	<.001	10	view →
KICH	Male	All	−0.870	<.001	9	view →
KIRP	Male	III,IV	−0.574	<.001	9	view →
BLCA	All	All	+0.297	<.001	9	view →
STAD	All	II,III,IV	+0.265	<.001	8	view →
KIRC	Male	II,III,IV	−0.455	<.001	7	view →
LUAD	Male	II,III,IV	+0.420	<.001	7	view →
HNSC	Male	III,IV	+0.224	.004	7	view →
BRCA	All	All	+0.138	.028	3	view →
PRAD	All	All	+0.168	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SEPTIN4-AS1–THCA

Open the THCA breakdown →