SEPTIN3

Across TCGA pan-cancer cohorts, SEPTIN3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SEPTIN3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SEPTIN3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SEPTIN3 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

LUAD, PDAC, and HNSC are the cancer types where SEPTIN3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.952	<.001	6	view →
PDAC	All	II,III,IV	−0.464	.003	6	view →
HNSC	Male	II,III,IV	−0.373	.010	5	view →
LSCC	All	All	+0.283	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SEPTIN3–LUAD

Open the LUAD breakdown →