SEPTIN3

Across TCGA pan-cancer cohorts, SEPTIN3 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated SEPTIN3 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SEPTIN3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEPTIN3 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

MESO, ACC, and UVM are the cancer types where SEPTIN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	II,III,IV	0.281	0.466	.001	109	view →
ACC	DFS	Median	All	0.327	0.820	<.001	108	view →
UVM	OS	Tertile	All	0.406	0.808	<.001	100	view →
LGG	DFS	Median	All	0.478	0.279	<.001	48	view →
UCEC	OS	Quartile	All	0.810	0.934	<.001	44	view →
COAD	DFS	Median	All	0.416	0.690	<.001	43	view →
KIRP	DFS	Tertile	II,III,IV	0.219	0.845	.003	42	view →
UCS	OS	Median	II,III,IV	0.637	0.205	.001	40	view →
HNSC	DFS	Tertile	IV	0.729	0.564	.007	33	view →
LIHC	OS	Tertile	All	0.711	0.875	<.001	21	view →
LUAD	OS	Median	II,III,IV	0.791	0.626	<.001	13	view →
SCLC	OS	Quartile	All	0.307	1.000	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

SEPTIN3–MESO (DFS)

Open the MESO breakdown →