SEPTIN3

Across TCGA patient cohorts, SEPTIN3 mutation is significantly associated with the RNA expression of many other genes, with 2,414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN3-associated genes across cancer lineages are RPS29P32, RNA5SP369, and RNU6-1064P. Each is linked with SEPTIN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEPTIN3-to-partner and partner-to-SEPTIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by SEPTIN3-low versus SEPTIN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN3→partner) and Y-score (partner→SEPTIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.383	+1.862	<.001	.009	3	4
UCEC	RNA5SP369 →	+0.325	+2.023	<.001	.002	3	3
BLCA	RNU6-1064P →	+0.887	+4.178	<.001	.009	3	2
BLCA	RPS3AP17 →	+0.094	+4.899	<.001	.005	3	2
STAD	OR4C50P →	+0.208	+4.646	<.001	.004	3	2
HNSC	LINC02782 →	+0.122	+5.063	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,414 associations by consensus.

RPS29P32 by SEPTIN3 expression — UCEC

Explore this box plot interactively →