SEPTIN3

Across TCGA patient cohorts, SEPTIN3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN3-associated genes across cancer lineages are Shc_pY317, MEK1, and S6. Each is linked with SEPTIN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEPTIN3-to-partner and partner-to-SEPTIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SEPTIN3-low versus SEPTIN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN3→partner) and Y-score (partner→SEPTIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.173	-2.700	.002	.006	3	3
UCEC	MEK1 →	+0.466	+2.662	<.001	<.001	3	2
COAD	S6 →	-0.480	-2.991	.010	.036	3	2
COAD	4E-BP1 →	+0.314	+3.008	.005	.019	3	2
UCEC	eIF4E →	+0.188	+2.169	.017	.003	3	2
UCEC	Notch1 →	+0.142	+2.232	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Shc_pY317 by SEPTIN3 expression — UCEC

Explore this box plot interactively →