SEPTIN3

Across TCGA cell cohorts, SEPTIN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,694 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEPTIN3-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of double-strand break repair, and Protein-DNA complex organization. Each is linked with SEPTIN3 in more than 14 cancer types. Because this analysis shows association rather than direction, both SEPTIN3-to-partner and partner-to-SEPTIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by SEPTIN3-low versus SEPTIN3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN3→partner) and Y-score (partner→SEPTIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA repair →	+0.076	+2.330	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.084	+1.418	<.001	.003	3	14
BONE	Protein-DNA complex organization →	+0.089	+1.895	.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.077	+0.646	<.001	.001	3	13
STOMACH	Ribonucleoside triphosphate biosynthetic process →	+0.109	+1.657	<.001	<.001	3	13
OVARY	Regulation of DNA repair →	+0.046	+1.174	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,694 associations by consensus.

Positive regulation of DNA repair by SEPTIN3 expression — BONE

Explore this box plot interactively →