SEPTIN2

Across TCGA patient cohorts, SEPTIN2 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN2-associated genes across cancer lineages are RNU1-143P, PABPC1L2B-AS1, and ENSAP3. Each is linked with SEPTIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN2-to-partner and partner-to-SEPTIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-143P grouped by SEPTIN2-low versus SEPTIN2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN2→partner) and Y-score (partner→SEPTIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU1-143P →	+0.362	+5.639	<.001	.002	3	2
COAD	PABPC1L2B-AS1 →	+0.032	+6.734	<.001	<.001	3	2
BRCA	ENSAP3 →	+0.193	+5.153	<.001	.001	3	2
HNSC	HMGN1P31 →	+0.151	+7.357	<.001	<.001	3	2
LUSC	RNU6-1060P →	+0.230	+5.081	<.001	.004	3	2
UCEC	ARPP19P2 →	+0.189	+2.161	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

RNU1-143P by SEPTIN2 expression — BRCA

Explore this box plot interactively →