SEPTIN14

Across TCGA pan-cancer cohorts, SEPTIN14 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SEPTIN14 data layer compared with 15 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEPTIN14 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SEPTIN14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUSC, and COAD are the cancer types where SEPTIN14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.827	.006	32	view →
LUSC	OS	Median	III,IV	0.119	0.673	<.001	12	view →
COAD	DFS	Median	All	0.119	0.556	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SEPTIN14–UCEC (DFS)

Open the UCEC breakdown →