SEPTIN12

Across TCGA patient cohorts, SEPTIN12 protein abundance is significantly associated with the protein abundance of many other proteins, with 25,956 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEPTIN12-associated proteins across cancer lineages are PBRM1_S1453, PGD_S257, and PLEC_T3634. Each is linked with SEPTIN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN12-to-partner and partner-to-SEPTIN12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPTIN12 versus PBRM1_S1453 in LUAD, with a Pearson correlation of -0.58.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN12→partner) and Y-score (partner→SEPTIN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PBRM1_S1453 →	-1.371	-0.788	.001	.001	3	1
LUAD	PGD_S257 →	-1.460	-0.929	<.001	.001	3	1
LUAD	PLEC_T3634 →	+0.787	+0.821	.003	<.001	3	1
LUAD	PLEC_T3785 →	+0.787	+0.821	.003	<.001	3	1
LUAD	PLEKHG4B →	+0.835	+0.637	<.001	<.001	3	1
LUAD	PNISR_S601 →	-0.605	-0.650	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,956 associations by consensus.

SEPTIN12 vs PBRM1_S1453 — LUAD

Explore this scatter interactively →