SEPTIN12

Across TCGA pan-cancer cohorts, SEPTIN12 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SEPTIN12 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SEPTIN12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SEPTIN12 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

KIRP, KIRC, and LIHC are the cancer types where SEPTIN12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.593	0.762	<.001	95	view →
KIRC	DFS	Median	All	0.554	0.684	<.001	93	view →
LIHC	OS	Tertile	II,III,IV	0.274	0.516	.001	68	view →
BRCA	OS	Median	All	0.978	0.946	.001	52	view →
ACC	OS	Tertile	All	0.439	0.921	.002	47	view →
DLBC	DFS	Quartile	IV	0.176	0.730	.008	30	view →
READ	DFS	Quartile	IV	0.255	0.690	.001	29	view →
HNSC	DFS	Tertile	III,IV	0.760	0.635	.017	15	view →
UCS	OS	Tertile	IV	0.156	0.783	.024	12	view →
CHOL	OS	Median	All	0.364	0.747	.037	11	view →
SCLC	OS	Median	II,III,IV	1.000	0.462	.005	11	view →
LGG	DFS	Tertile	All	0.664	0.796	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SEPTIN12–KIRP (OS)

Open the KIRP breakdown →