SEPTIN12

Across TCGA patient cohorts, SEPTIN12 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEPTIN12-associated genes across cancer lineages are Gab2, Ku80, and Tuberin. Each is linked with SEPTIN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN12-to-partner and partner-to-SEPTIN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by SEPTIN12-low versus SEPTIN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN12→partner) and Y-score (partner→SEPTIN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.365	+2.222	.016	.011	3	2
UCEC	Ku80 →	+0.205	+1.713	.041	.027	3	2
UCEC	Tuberin →	+0.335	+3.469	.003	.002	3	2
UCEC	C-Raf →	+0.204	+3.321	<.001	.010	3	2
SKCM	ER-alpha_pS118 →	+0.138	+3.000	.021	.034	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.957	+2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Gab2 by SEPTIN12 expression — UCEC

Explore this box plot interactively →