SEPTIN12

Across TCGA cell cohorts, SEPTIN12 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,345 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SEPTIN12-associated GO terms across cancer lineages are Regulation of blood pressure, Regulation of potassium ion transmembrane transport, and Megakaryocyte development. Each is linked with SEPTIN12 in more than 5 cancer types. Because this analysis shows association rather than direction, both SEPTIN12-to-partner and partner-to-SEPTIN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of blood pressure grouped by SEPTIN12-low versus SEPTIN12-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN12→partner) and Y-score (partner→SEPTIN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of blood pressure →	-0.079	-0.350	<.001	.002	3	6
OVARY	Regulation of potassium ion transmembrane transport →	-0.103	-0.104	<.001	.003	3	6
LIVER	Megakaryocyte development →	-0.171	-0.130	.005	.008	3	6
OVARY	Heterochromatin formation →	+0.052	+0.098	.003	.008	3	5
CNS	Negative regulation of DNA-templated transcription, elongation →	+0.065	+0.052	<.001	.008	2	6
SOFT_TISSUE	Negative regulation of transcription elongation by RNA polymerase II →	+0.046	+0.114	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,345 associations by consensus.

Regulation of blood pressure by SEPTIN12 expression — BREAST

Explore this box plot interactively →