SEPTIN12

Across TCGA cell cohorts, SEPTIN12 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SEPTIN12-associated genes across cancer lineages are RASGEF1C, OR4D5, and OR10T2. Each is linked with SEPTIN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN12-to-partner and partner-to-SEPTIN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASGEF1C grouped by SEPTIN12-low versus SEPTIN12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN12→partner) and Y-score (partner→SEPTIN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.207	+3.333	.009	.009	3	1
LUNG_SCLC	OR4D5 →	+0.080	+4.523	.001	.003	3	1
LUNG_SCLC	OR10T2 →	+0.169	+4.044	<.001	.009	3	1
LUNG_SCLC	C8orf89 →	+0.078	+4.269	<.001	.005	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.711	+3.252	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

RASGEF1C by SEPTIN12 expression — LARGE_INTESTINE

Explore this box plot interactively →