SEPTIN11

Across TCGA cell cohorts, SEPTIN11 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SEPTIN11-associated genes across cancer lineages are KRTAP10-10, DEFB118, and TCP10L2. Each is linked with SEPTIN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN11-to-partner and partner-to-SEPTIN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-10 grouped by SEPTIN11-low versus SEPTIN11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN11→partner) and Y-score (partner→SEPTIN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-10 →	+0.068	+3.347	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB118 →	+0.010	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.036	+5.472	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR2AK2 →	+0.022	+4.947	.002	.001	3	1
LUNG_NSCLC_LUAD	OR2M3 →	+0.084	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRTAP10-10 by SEPTIN11 expression — LARGE_INTESTINE

Explore this box plot interactively →