SEPTIN1

Across TCGA patient cohorts, SEPTIN1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,140 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEPTIN1-associated genes across cancer lineages are APOBEC3H, GRAP2, and IL2RB. Each is linked with SEPTIN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SEPTIN1-to-partner and partner-to-SEPTIN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEPTIN1 versus APOBEC3H in BRCA, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN1→partner) and Y-score (partner→SEPTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APOBEC3H →	+0.816	+0.802	<.001	<.001	3	10
HNSC	GRAP2 →	+0.911	+0.704	<.001	<.001	3	10
BRCA	IL2RB →	+1.461	+0.979	<.001	<.001	3	10
BRCA	SLA2 →	+1.225	+0.977	<.001	<.001	3	10
OV	MAP4K1 →	+1.118	+0.754	<.001	<.001	3	10
LSCC	RASAL3 →	+1.029	+0.897	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,140 associations by consensus.

SEPTIN1 vs APOBEC3H — BRCA

Explore this scatter interactively →