SEPTIN1

Across TCGA pan-cancer cohorts, SEPTIN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SEPTIN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEPTIN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEPTIN1 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where SEPTIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEPTIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.577	<.001	11	view →
COAD	Female	III,IV	−0.962	<.001	9	view →
BLCA	All	All	−0.826	.002	7	view →
UCEC	All	II,III,IV	−1.368	<.001	6	view →
LUSC	All	All	−0.532	<.001	6	view →
LIHC	Female	All	+0.741	.001	5	view →
THCA	All	All	−0.563	.004	4	view →
KIRP	All	III,IV	+0.472	.022	3	view →
CHOL	All	All	+0.946	.022	2	view →
BRCA	All	IV	−0.935	.022	2	view →
ESCA	All	All	+0.621	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SEPTIN1–KIRC

Open the KIRC breakdown →