SEPTIN1

Across TCGA cell cohorts, SEPTIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,194 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPTIN1-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Positive regulation of intracellular estrogen receptor signaling pathway, and Regulation of ATPase-coupled calcium transmembrane transporter activity. Each is linked with SEPTIN1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SEPTIN1-to-partner and partner-to-SEPTIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SEPTIN1-low versus SEPTIN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN1→partner) and Y-score (partner→SEPTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.184	+0.553	<.001	.003	3	15
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.205	+0.551	<.001	.001	2	16
SOFT_TISSUE	Regulation of ATPase-coupled calcium transmembrane transporter activity →	-0.249	-0.655	<.001	<.001	3	13
BONE	Calcium-independent cell-matrix adhesion →	+0.279	+0.738	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.155	+0.607	<.001	<.001	3	12
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.140	+0.564	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,194 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SEPTIN1 expression — BONE

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