SEPTIN1

Across TCGA cell cohorts, SEPTIN1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEPTIN1-associated genes across cancer lineages are OPN1LW, MT1B, and SLC32A1. Each is linked with SEPTIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEPTIN1-to-partner and partner-to-SEPTIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN1LW grouped by SEPTIN1-low versus SEPTIN1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEPTIN1→partner) and Y-score (partner→SEPTIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OPN1LW →	+0.038	+5.169	<.001	.005	3	1
BREAST	MT1B →	+0.113	+5.169	<.001	.005	3	1
BLOOD_Leukemia	SLC32A1 →	+0.834	+3.901	<.001	.006	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	GPR101 →	+0.108	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OPN1LW by SEPTIN1 expression — BREAST

Explore this box plot interactively →