SENP6

Across TCGA pan-cancer cohorts, SENP6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SENP6 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SENP6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SENP6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where SENP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.948	0.520	<.001	34	view →
HNSC	DFS	Quartile	All	1.000	0.934	.036	5	view →
PDAC	DFS	Median	III,IV	0.528	0.175	.011	5	view →
LSCC	OS	Quartile	All	0.899	0.696	.013	2	view →
UCEC	OS	Median	All	0.910	0.983	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SENP6–CCRCC (DFS)

Open the CCRCC breakdown →