SENP6

Across TCGA pan-cancer cohorts, SENP6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SENP6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SENP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SENP6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where SENP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SENP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.622	<.001	12	view →
THCA	All	II,III,IV	−0.529	<.001	8	view →
KICH	Female	All	−1.156	<.001	7	view →
LIHC	All	All	+0.341	.001	6	view →
CHOL	All	All	+1.315	<.001	4	view →
UCEC	All	All	−0.541	.001	2	view →
KIRP	Male	All	−0.489	<.001	2	view →
BRCA	Female	All	−0.168	.029	2	view →
ESCA	Female	All	+0.503	.042	1	view →
LUAD	Female	II,III,IV	−0.431	.007	1	view →
KIRC	Male	III,IV	−0.319	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SENP6–HNSC

Open the HNSC breakdown →