SENP6

Across TCGA patient cohorts, SENP6 mutation is significantly associated with the RNA expression of many other genes, with 2,691 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP6-associated genes across cancer lineages are PLK1, PGAM1, and ACOT7. Each is linked with SENP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SENP6-to-partner and partner-to-SENP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLK1 grouped by SENP6-low versus SENP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP6→partner) and Y-score (partner→SENP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLK1 →	+0.509	+2.606	.007	<.001	3	3
UCEC	PGAM1 →	+0.536	+1.684	.005	.006	3	3
UCEC	ACOT7 →	+0.593	+1.765	<.001	<.001	3	3
UCEC	CDCA2 →	+0.710	+2.606	<.001	<.001	3	3
UCEC	NF2 →	+0.509	+2.010	<.001	<.001	3	3
UCEC	TTC30B →	-0.439	-2.311	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,691 associations by consensus.

PLK1 by SENP6 expression — UCEC

Explore this box plot interactively →