SENP6

Across TCGA patient cohorts, SENP6 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP6-associated genes across cancer lineages are ATM, eIF4E, and INPP4B. Each is linked with SENP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SENP6-to-partner and partner-to-SENP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SENP6-low versus SENP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP6→partner) and Y-score (partner→SENP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.604	-1.938	<.001	.001	3	3
UCEC	eIF4E →	+0.168	+3.598	.015	.001	3	2
UCEC	INPP4B →	-0.268	-2.321	.011	.005	3	2
UCEC	MEK1 →	+0.416	+1.938	<.001	.001	3	2
UCEC	Annexin-1 →	+0.503	+1.926	.003	.008	3	2
UCEC	CD49b →	-0.270	-1.980	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by SENP6 expression — UCEC

Explore this box plot interactively →