SENP6

Across TCGA cell cohorts, SENP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,116 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP6-associated GO terms across cancer lineages are Regulation of kinetochore assembly, 7-methylguanosine RNA capping, and Regulation of formation of translation preinitiation complex. Each is linked with SENP6 in more than 14 cancer types. Because this analysis shows association rather than direction, both SENP6-to-partner and partner-to-SENP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of kinetochore assembly grouped by SENP6-low versus SENP6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP6→partner) and Y-score (partner→SENP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of kinetochore assembly →	+0.122	+0.792	<.001	<.001	3	15
OVARY	7-methylguanosine RNA capping →	+0.119	+0.701	<.001	<.001	3	15
BREAST	Regulation of formation of translation preinitiation complex →	+0.085	+0.785	<.001	<.001	3	15
BREAST	Negative regulation of formation of translation preinitiation complex →	+0.085	+0.785	<.001	<.001	3	15
OVARY	7-methylguanosine mRNA capping →	+0.119	+0.701	<.001	<.001	3	15
LUNG_SCLC	CRD-mediated mRNA stabilization →	+0.168	+0.665	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,116 associations by consensus.

Regulation of kinetochore assembly by SENP6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →