SENP6

Across TCGA cell cohorts, SENP6 mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP6-associated genes across cancer lineages are MTRNR2L1, POU2AF1, and RNF8. Each is linked with SENP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP6-to-partner and partner-to-SENP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L1 grouped by SENP6-low versus SENP6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP6→partner) and Y-score (partner→SENP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTRNR2L1 →	+0.104	+3.781	<.001	.008	3	2
LARGE_INTESTINE	POU2AF1 →	+0.760	+3.125	.002	.008	3	1
LARGE_INTESTINE	RNF8 →	+0.481	+3.212	.009	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1
LARGE_INTESTINE	CSN2 →	+0.016	+2.514	.002	.007	3	1
LARGE_INTESTINE	SRPK2 →	+0.524	+3.299	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

MTRNR2L1 by SENP6 expression — CNS

Explore this box plot interactively →