SENP3

Across TCGA patient cohorts, SENP3 mutation is significantly associated with the RNA expression of many other genes, with 2,711 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SENP3-associated genes across cancer lineages are TCERG1L-AS1, MTCO2P4, and RN7SL841P. Each is linked with SENP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SENP3-to-partner and partner-to-SENP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCERG1L-AS1 grouped by SENP3-low versus SENP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP3→partner) and Y-score (partner→SENP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCERG1L-AS1 →	+0.316	+1.811	<.001	<.001	3	3
BRCA	MTCO2P4 →	+1.658	+5.683	<.001	.004	3	2
SKCM	RN7SL841P →	+0.105	+4.614	<.001	.006	3	2
LGG	RNU6-1298P →	+0.243	+7.977	<.001	.007	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
LUSC	LINC01517 →	+0.177	+5.093	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,711 associations by consensus.

TCERG1L-AS1 by SENP3 expression — UCEC

Explore this box plot interactively →