SENP1

Across TCGA cell cohorts, SENP1 mutation is significantly associated with the RNA expression of many other genes, with 433 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SENP1-associated genes across cancer lineages are KCNA4, C14orf180, and GGA1. Each is linked with SENP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SENP1-to-partner and partner-to-SENP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA4 grouped by SENP1-low versus SENP1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SENP1→partner) and Y-score (partner→SENP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KCNA4 →	+0.305	+4.129	.002	.002	3	1
UPPER_AERODIGESTIVE_TRACT	C14orf180 →	+0.005	+3.510	<.001	.007	3	1
LARGE_INTESTINE	GGA1 →	+0.622	+2.502	.002	.005	3	1
LARGE_INTESTINE	SGSM3 →	+0.780	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.672	+2.502	<.001	.005	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.513	+3.321	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 433 associations by consensus.

KCNA4 by SENP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →