SEMG2

Across TCGA patient cohorts, SEMG2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMG2-associated genes across cancer lineages are PCNA, FoxM1, and p38-MAPK_pT180_Y182. Each is linked with SEMG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMG2-to-partner and partner-to-SEMG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SEMG2-low versus SEMG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMG2→partner) and Y-score (partner→SEMG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.262	+2.169	.001	.003	3	4
UCEC	FoxM1 →	+0.226	+1.765	.019	.014	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.338	-1.401	.045	.046	3	3
UCEC	Cyclin-B1 →	+0.560	+3.459	.007	.005	3	3
UCEC	Bak →	+0.202	+1.700	.032	.042	3	2
UCEC	Caspase-7-cleavedD198 →	+0.455	+2.019	.041	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by SEMG2 expression — UCEC

Explore this box plot interactively →