SEMG2

Across TCGA pan-cancer cohorts, SEMG2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SEMG2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMG2 RNA is repressed in tumor relative to normal tissue. In most cancer types SEMG2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where SEMG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.717	<.001	12	view →
KICH	Male	II,III,IV	−1.916	<.001	10	view →
KIRP	All	II,III,IV	−1.004	<.001	9	view →
BRCA	All	II,III,IV	+0.030	.035	4	view →
PRAD	All	All	−2.837	<.001	2	view →
COAD	All	II,III,IV	+0.302	.042	2	view →
UCEC	All	All	+0.179	.024	2	view →
HNSC	All	II,III,IV	−0.092	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SEMG2–KIRC

Open the KIRC breakdown →